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Related Concept Videos

Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...

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Related Experiment Video

Updated: Jun 26, 2026

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
08:06

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Published on: November 27, 2019

Fat rationing in dauer times.

Katherine A Cunningham1, Kaveh Ashrafi

  • 1Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.

Cell Metabolism
|February 4, 2009
PubMed
Summary
This summary is machine-generated.

Maintaining energy balance is crucial for survival, especially during nutrient scarcity. The AMP kinase pathway helps Caenorhabditis elegans conserve energy for long-term survival in dauer larvae.

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Area of Science:

  • Cellular Biology
  • Metabolism
  • Developmental Biology

Background:

  • Energy balance is vital for organismal survival.
  • Nutrient availability significantly impacts energy homeostasis.
  • Maintaining energy stores is critical under conditions of scarcity or dynamic nutrient levels.

Purpose of the Study:

  • To investigate the role of the AMP kinase pathway in energy management.
  • To understand how energy stores are rationed for long-term survival.
  • To explore the mechanisms governing survival in Caenorhabditis elegans dauer larvae.

Main Methods:

  • Utilized Caenorhabditis elegans as a model organism.
  • Focused on the AMP kinase pathway.
  • Analyzed energy rationing strategies in dauer larvae.

Main Results:

  • The AMP kinase pathway plays a key role in conserving energy resources.
  • This pathway is essential for the long-term survival of dauer larvae.
  • Energy rationing is a critical survival mechanism.

Conclusions:

  • The AMP kinase pathway is a critical regulator of energy homeostasis during nutrient stress.
  • Conserving energy is a fundamental strategy for long-term survival in adverse conditions.
  • This study provides insights into the molecular mechanisms underlying stress adaptation in C. elegans.