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CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling

Fabienne T Schulthess1, Federico Paroni, Nadine S Sauter

  • 1Larry L. Hillblom Islet Research Center, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

Cell Metabolism
|February 4, 2009
PubMed
Summary

Interferon gamma-inducible protein 10 (CXCL10) promotes beta cell failure in diabetes by inducing apoptosis. This protein, elevated in diabetic patients, signals through TLR4, not CXCR3, contributing to disease progression.

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