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Updated: Jun 26, 2026

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
Published on: December 15, 2017
Functional imaging of inflammatory diseases using nuclear medicine techniques
Sandip Basu1, Hongming Zhuang, Drew A Torigian
1Radiation Medicine Center (BARC), Tata Memorial Hospital Annex, Mumbai, India.
Molecular imaging, particularly (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET), is crucial for diagnosing and monitoring various inflammatory diseases. This functional imaging technique offers significant advancements in managing conditions like sarcoidosis, atherosclerosis, and rheumatoid arthritis.
Area of Science:
- Nuclear Medicine
- Radiopharmacology
- Diagnostic Imaging
Background:
- Molecular imaging using PET and SPECT is vital for inflammatory disorders.
- Common agents include (67)Ga citrate, (99m)Tc/ (111)In leukocytes, and (18)F-fluorodeoxyglucose (FDG).
- Novel agents are also being explored for inflammation detection.
Purpose of the Study:
- To review the role of molecular imaging, especially FDG-PET, in inflammatory diseases.
- To highlight the diagnostic and monitoring capabilities of FDG-PET.
- To discuss the future potential of functional imaging in managing inflammatory conditions.
Main Methods:
- Review of current radiopharmaceutical agents used in PET and SPECT.
- Focus on the application and efficacy of FDG-PET in various inflammatory conditions.
- Comparison of FDG-PET with other imaging modalities.
Main Results:
- FDG-PET is highly effective for detecting and monitoring inflammation in conditions such as sarcoidosis, atherosclerosis, vasculitis, RA, and IBD.
- (99m)Tc-HMPAO-labeled leukocytes are recommended for abdominal inflammation.
- (99m)Tc nanocolloid is suitable for bone and joint diseases.
Conclusions:
- FDG-PET imaging is a powerful tool that is becoming central to managing inflammatory disorders.
- Functional imaging, led by FDG-PET, will significantly improve the assessment and management of inflammatory diseases.
- FDG-PET offers valuable insights into pulmonary, extrapulmonary, and vascular inflammation, as well as joint diseases.
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