Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nucleus-level thalamic organization anchors multimodal signatures of thalamocortical maturation.

bioRxiv : the preprint server for biology·2026
Same author

A combination of ketones and NAD<sup>+</sup> precursor preserves white matter integrity in mild cognitive impairment.

Alzheimer's & dementia (New York, N. Y.)·2026
Same author

A new method for optimal placement of tumor treating fields electrodes.

Neuro-oncology advances·2026
Same author

Automated Segmentation of Brainstem and Subcortical White Matter: Mapping the Deep Tegmental Core with BundleParc.

bioRxiv : the preprint server for biology·2026
Same author

Disentangling crossing fibers with advanced dMRI methods reveals bundle-specific degeneration across the visual system in asymmetric glaucoma.

PloS one·2026
Same author

BundleParc: Consistent white matter bundle parcellation without tractography.

Medical image analysis·2026

Related Experiment Video

Updated: Jun 26, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Deterministic and probabilistic tractography based on complex fibre orientation distributions.

Maxime Descoteaux1, Rachid Deriche, Thomas R Knösche

  • 1LNAO Laboratory, NeuroSpin, CEA/Saclay, 91191 Paris, France.

IEEE Transactions on Medical Imaging
|February 4, 2009
PubMed
Summary

This study introduces a new method for brain white matter tractography using fibre orientation distribution functions (ODFs) from high angular resolution diffusion imaging (HARDI). This approach improves the accuracy of mapping complex fibre pathways, overcoming limitations of current diffusion tensor imaging (DTI) methods.

More Related Videos

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions
10:05

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Related Experiment Videos

Last Updated: Jun 26, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions
10:05

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Area of Science:

  • Neuroimaging
  • Computational Neuroscience
  • Medical Physics

Background:

  • Accurate mapping of white matter tracts is crucial for understanding brain function and disease.
  • Current diffusion tensor imaging (DTI) methods struggle with complex fibre configurations like crossings and splits.
  • High angular resolution diffusion imaging (HARDI) offers richer data but requires advanced processing.

Purpose of the Study:

  • To develop an integral concept for tractography using fibre orientation distribution functions (ODFs) to accurately describe crossing and splitting fibre bundles.
  • To introduce a novel sharpening deconvolution transform (SDT) for estimating fibre ODFs from HARDI data.
  • To create new deterministic and probabilistic tractography algorithms leveraging the full multidirectional information from fibre ODFs.

Main Methods:

  • Estimation of fibre ODFs using a sharpening deconvolution transform (SDT) applied to diffusion ODFs reconstructed from q-ball imaging (QBI).
  • Development and implementation of novel deterministic and probabilistic tractography algorithms utilizing the computed fibre ODFs.
  • Extensive comparison of the new algorithms against existing methods on human brain datasets, focusing on complex fibre crossing regions.

Main Results:

  • The proposed SDT method provides improved angular resolution compared to standard QBI and agrees with classical spherical deconvolution.
  • New deterministic and probabilistic tractography algorithms demonstrate enhanced ability to reconstruct complex fibre pathways, including crossings.
  • Quantification of transcallosal fibres intersecting with the corona radiata and superior longitudinal fasciculus in a cohort of eight subjects.

Conclusions:

  • Accurate tractography requires fibre ODF estimation, not just diffusion ODF, for resolving complex white matter architecture.
  • The SDT method and new tractography algorithms offer a significant advancement in mapping brain connectivity.
  • This improved tractography can lead to more accurate interpretations of brain function and potentially aid in diagnosing neurological disorders.