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Specific IgE response to trichophyton and asthma severity
Hirofumi Matsuoka1, Akio Niimi1, Hisako Matsumoto1
1Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Chest
|February 4, 2009
Summary
Allergen sensitization to Trichophyton, a common mold, is linked to increased asthma severity. This study found higher Trichophyton-specific IgE levels in patients with moderate and severe asthma compared to controls and mild asthma patients.
Area of Science:
- Allergen immunotherapy
- Dermatology
- Pulmonology
Background:
- Sensitization to Trichophyton, a prevalent dermatophyte, is implicated in asthma development.
- The relationship between Trichophyton sensitization and asthma severity, similar to other molds like Alternaria, remains unclear.
Purpose of the Study:
- To investigate the association between Trichophyton sensitization and asthma severity.
- To compare IgE titers against Trichophyton and other common allergens across different asthma severity groups.
Main Methods:
- A cohort of 258 asthma patients (mild, moderate, severe) and 114 healthy controls were analyzed.
- Specific IgE titers against Trichophyton rubrum and other allergens (molds, dust mites, dander, pollens) were measured.
- Multivariate analysis was employed to determine independent factors associated with asthma severity.
Main Results:
- Trichophyton-specific IgE positivity was significantly higher in moderate (15.8%) and severe (32.4%) asthma groups compared to controls (7.0%) and mild asthma (4.9%).
- Positive IgE for Trichophyton was identified as an independent determinant of asthma severity.
- Cross-reactivity with other molds was considered and did not negate the observed trend.
Conclusions:
- Specific IgE responses to Trichophyton are associated with increased asthma severity.
- Trichophyton sensitization may serve as a biomarker for more severe asthma cases.
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