Related Experiment Video
Updated: Jun 26, 2026

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells
Published on: April 18, 2019
Stem cells and tissue-engineered skin
1Department of Dermatology, University of California and Veterans Affairs Medical Center, San Francisco, CA, USA.
Abstract:
Advances in tissue engineering of skin are needed for clinical applications (as in wound healing and gene therapy) for cutaneous and systemic diseases. In this paper we review the use of epidermal stem cells as a source of cells to improve tissue-engineered skin. We discuss the importance and limitations of epidermal stem cell isolation using biomarkers, in quest of a pure stem cell preparation, as well as the culture conditions necessary to maintain this purity as required for a qualitatively superior and long-lasting engineered skin. Finally, we review the advantages of using additional multipotent stem cell sources to functionally and cosmetically optimize the engineered tissue.
Related Concept Videos
Clinical Applications of Epidermal Stem Cells
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
iPS Cell Differentiation
Renewal of Skin Epidermal Stem Cells
Induced Pluripotent Stem Cells
Induced Pluripotent Stem Cells
Somatic cells are...

