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Updated: Jun 26, 2026
06:38
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Kidney cancer: the new landscape
Jennifer A Linehan1, Mike M Nguyen
1Section of Urology, Arizona Health Sciences Center, The University of Arizona, Tucson, AZ, USA.
Current Opinion in Urology
|February 4, 2009
Summary
Renal cancer treatment now prioritizes kidney preservation, shifting from radical surgery to nephron-sparing approaches. Early detection of smaller tumors allows for more treatment options and better outcomes.
Area of Science:
- Oncology
- Urology
Background:
- The management of renal cancer has evolved significantly over time.
- Historically, radical nephrectomy was the standard treatment for renal tumors.
Purpose of the Study:
- To review the changing patterns in renal cancer presentation.
- To understand how evolving clinical behavior and diagnostic methods have influenced treatment philosophy.
Main Methods:
- Review of recent epidemiological trends in renal cancer.
- Analysis of changes in tumor size, metastatic rates, and patient demographics.
- Evaluation of the impact of advanced imaging on incidental diagnoses.
Main Results:
- Increasing incidence of renal cancer in the USA and variable trends in Europe.
- Higher rates of incidental diagnosis, leading to smaller tumors at presentation.
- Decreased incidence of metastasis and a slight increase in mean age at diagnosis.
- Active surveillance data indicate many small renal masses have low metastatic potential.
Conclusions:
- Renal cancer presentation has shifted towards incidentally detected, smaller, localized tumors in an older population.
- Expanded treatment options, including focal therapies, are now available.
- Emphasis is placed on preserving renal function and minimizing treatment-related morbidity.
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