Related Experiment Video
Updated: Jun 26, 2026
Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma
Published on: August 31, 2022
Hypervascular focus in the nonhypervascular nodule ("nodule-in-nodule") on dynamic computed tomography: imaging
Jeong-Sik Yu1, Jae-Joon Chung, Joo Hee Kim
1Department of Radiology and the Research Institute of Radiological Science, Yonsei University College of Medicine, YongDong Severance Hospital, Seoul, Republic of Korea. yjsrad97@yumc.yonsei.ac.kr
Objective:
The purpose of this study was to investigate the early manifestation of hypervascular hepatocellular carcinomas by means of evaluating the "nodule-in-nodule" hepatic lesions depicted on dynamic computed tomography.
Methods:
For 26 lesions with hypervascular foci in nonhypervascular nodules in 23 patients with cirrhotic liver, the size of the lesions was measured during the initial and follow-up studies in patients who had a comparable follow-up computed tomography or magnetic resonance imaging studies (ranging from 46 to 399 days).
Results:
The mean volume doubling time of the total 26 inner nodules was 36 days, which was significantly shorter than the doubling time for the outer nodules (mean, 257 days for 18 enlarged lesions) (P < 0.001).
Conclusions:
Because of the rapid progression of the inner hypervascular hepatocellular carcinomas, recognition of nodule-in-nodule lesions is essential for considering short-term follow-up or immediate treatment when managing patients with cirrhosis.
More Related Videos
07:32Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software
Published on: April 12, 2024
08:55Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
Published on: April 15, 2016