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The association of serum lipids with renal function: the Korea Medical Institute Study

Hee Jin Kim1, Sun Ha Jee, Sun Ju Lee

  • 1aInstitute for Health Promotion, Graduate School of Public Health, Yonsei University bKorea Medical Institute, Seoul, Republic of Korea.

European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
|February 4, 2009
PubMed

Insights

Elevated lipid biomarkers are linked to reduced kidney function (GFR < 60 ml/min) in Korean adults. This association highlights the connection between renal insufficiency and cardiovascular disease risk.

Area of Science:

  • Cardiovascular epidemiology
  • Nephrology
  • Clinical biochemistry

Background:

  • Serum lipids and renal dysfunction are established cardiovascular disease risk factors.
  • Limited data exist on lipid profiles and glomerular filtration rates (GFRs) with low serum cholesterol in Asian populations.

Purpose of the Study:

  • To investigate the relationship between serum lipid biomarkers and estimated GFR in a large Korean cohort.
  • To explore potential sex-specific differences in these associations.

Main Methods:

  • A cross-sectional study of 93,228 Korean individuals from the Korea Medical Institute Study.
  • Glomerular filtration rate (GFR) was estimated using the simplified modification of diet in renal disease (MDRD) equation based on serum creatinine.

Main Results:

  • Higher quartiles of most lipid biomarkers were significantly associated with a GFR < 60 ml/min/1.73 m².
  • In men, triglycerides and the TG/HDL ratio showed the strongest associations.
  • In women, low-density lipoprotein and non-HDL cholesterol exhibited the highest odds ratios. Associations were amplified in diabetic men.

Conclusions:

  • Potentially modifiable lipid biomarkers are elevated in individuals with GFR < 90 ml/min/1.73 m².
  • The study suggests a link between renal insufficiency and increased cardiovascular event risk in the Korean population.
Abstract

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