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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Long non-coding RNAs: insights into functions.

Tim R Mercer1, Marcel E Dinger, John S Mattick

  • 1Australian Research Council Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.

Nature Reviews. Genetics
|February 4, 2009
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (ncRNAs) are abundant in eukaryotes and play crucial roles in gene regulation. This review covers their conservation, genomic organization, functions, and medical relevance.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Biochemistry

Background:

  • Most of the eukaryotic genome is transcribed into long non-coding RNAs (ncRNAs) in a developmentally regulated manner.
  • Long ncRNAs are increasingly recognized for their diverse biological functions.

Purpose of the Study:

  • To review the rapidly advancing field of long ncRNAs.
  • To describe their conservation, genomic organization, and roles in gene regulation.
  • To consider their medical implications.

Main Methods:

  • Literature review of recent advancements in long ncRNA research.
  • Analysis of data on ncRNA conservation and genomic organization.
  • Synthesis of findings on the functional roles of long ncRNAs in gene regulation.

Main Results:

  • Long ncRNAs are a significant component of the transcriptome in mammals and other eukaryotes.
  • These molecules exhibit varying degrees of conservation and specific genomic organization.
  • Long ncRNAs are involved in diverse gene regulatory mechanisms.

Conclusions:

  • The field of long ncRNAs is rapidly evolving, revealing their fundamental importance.
  • Any RNA transcript, irrespective of coding potential, can possess intrinsic functional roles.
  • Understanding long ncRNAs has significant implications for medicine and biology.