Stepwise synthesis of RNA conjugates carrying peptide sequences for RNA interference studies
Anna Aviñó1, Sandra M Ocampo, Clara Caminal
1Institute for Research in Biomedicine Barcelona, Edifici Helix, Baldiri Reixac 15, 08028 Barcelona, Spain.
Molecular Diversity
|February 4, 2009
Abstract:
Oligoribonucleotide conjugates carrying nuclear localization peptide sequences at the 3'-end were prepared stepwise on a single support. The siRNA duplex carrying the nuclear localization peptide sequence at the 3'-end of the passenger strand has similar inhibitory properties as those of unmodified or cholesterol-modified RNA duplexes.
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