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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

[Endothelial dysfunction in children's chronic glomerulonephritis]

T V Sergeeva, T V Margieva, I E Smirnov

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |February 4, 2009
    PubMed

    Insights

    Endothelial dysfunction (ED) is present in children with chronic glomerulonephritis, persisting even in remission. ED markers indicate disease severity and prognosis, influencing progression through sclerotic and proliferative pathways.

    Area of Science:

    • Nephrology
    • Pediatric Nephrology
    • Cardiovascular Research

    Context:

    • Chronic glomerulonephritis in children.
    • Endothelial dysfunction (ED) as a pathological process.
    • Established markers of endothelial dysfunction and their role in kidney disease.

    Purpose:

    • To investigate the presence and characteristics of endothelial dysfunction in pediatric chronic glomerulonephritis.
    • To correlate markers of ED with disease activity, clinical form, and severity.
    • To evaluate the prognostic value of ED markers in children with chronic glomerulonephritis.

    Summary:

    • Production of nitric oxide (NO), soluble vascular cell adhesion molecule-1 (sVCAM-1), endothelin-1 (Et-1), factor V (FV), and plasminogen activator inhibitor-1 (PAI-1) was measured in children with chronic glomerulonephritis.
    • Endothelial dysfunction was observed in the active phase and persisted during remission, irrespective of the glomerulonephritis form.
    • The severity of ED and its markers varied with the morphological type of glomerulonephritis, with higher endothelin-1 in sclerotic forms and hypertension.
    • ED was linked to hemostasis activation, promoting a prothrombotic state and contributing to glomerulonephritis progression via sclerosis and cell proliferation.
    • Specific ED markers demonstrated prognostic value in pediatric chronic glomerulonephritis.

    Impact:

    • Highlights the significant role of endothelial dysfunction in pediatric chronic glomerulonephritis.
    • Identifies specific ED markers with prognostic value for disease progression and outcomes.
    • Suggests potential therapeutic targets for managing endothelial dysfunction in this population.

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