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Updated: Jun 25, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
Published on: December 13, 2017
Essential tremor after ipsilateral cerebellar hemispherectomy: support for the thalamus as the central oscillator
Lama M Chahine1, Debabrata Ghosh
1Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Abstract:
Essential tremor is a long-recognized and common movement disorder, yet controversy still surrounds its pathophysiology. The olivo-cerebello-thalamo-cortical pathway has been implicated in the genesis of essential tremor, and the inferior olive has been considered the central oscillator driving the peripheral tremor. We present the case of a patient who developed essential tremor ipsilateral to cerebellar hemispherectomy and propose that the central oscillator in patients with essential tremor may not be the inferior olive in all cases, but rather the nucleus ventralis intermedius of the thalamus.
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