Related Experiment Video
Updated: Jun 25, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
Long-term use of low-molecular-weight heparin in hemodialysis patients: a 7-year experience
B Bernieh1, Y Boobes, M R Al Hakim
1Nephrology Department, Tawam Hospital - Johns Hopkins Medicine, Al Ain, United Arab Emirates. bassambernieh@hotmail.com
Background:
Low-molecular-weight-heparin (LMWH) is not routinely used as anticoagulant in hemodialysis (HD). The ideal dose and the safety of long-term use are not known.
Methods:
A prospective three-phase interventional study. Phase 1 involved dose titration, phase 2 safety and efficacy and phase 3 routine practice.
Results:
During 7 years of the use of the LMWH enoxaparin (EN), 236 patients were treated with a total number of 60,987 HD sessions. The mean dose used during the titration phase was 0.43 +/- 0.16 mg/kg/session, which was subsequently reduced in phase 3 to 0.36 +/- 0.14 mg/kg/session. The long-term effects of EN on the platelet count and lipid profile were comparable to unfractionated heparin.
Conclusion:
The long-term use of LMWH (EN) with a reduced dose in HD is practical and safe.
Related Concept Videos
Hemodialysis II: Procedure and Complications
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Hemodialysis I: Introduction
Hemodialysis III: Nursing Management
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
Venous Thrombosis III: Interprofessional Care