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Updated: Jun 25, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
Successful electroconvulsive therapy in a patient with intellectual disability and bipolar disorder, with catatonic
Adam Ligas1, Georgios Petrides, Rafik Istafanous
1UMDNJ-New Jersey Medical School, Newark, NJ 07101-1709, USA.
We describe the successful use of electroconvulsive therapy (ECT) in a 39-year-old woman with a complex clinical picture including bipolar disorder with catatonic features superimposed on a history of multiple congenital anomalies and intellectual and developmental disabilities. At age 34, the patient presented with marked regression and behavioral disturbance diagnosed as encephalopathy. Multiple medical evaluations were inconclusive, and treatment courses with antibiotics and steroids failed. After psychiatric evaluation, her condition was diagnosed as bipolar disorder with catatonic features. She was treated with ECT with dramatic improvement and resumption of her premorbid level of functioning. We discuss the relevant literature on the use of ECT in patients with intellectual disability.
We describe the successful use of electroconvulsive therapy (ECT) in a 39-year-old woman with a complex clinical picture including bipolar disorder with catatonic features superimposed on a history of multiple congenital anomalies and intellectual and developmental disabilities. At age 34, the patient presented with marked regression and behavioral disturbance diagnosed as encephalopathy. Multiple medical evaluations were inconclusive, and treatment courses with antibiotics and steroids failed. After psychiatric evaluation, her condition was diagnosed as bipolar disorder with catatonic features. She was treated with ECT with dramatic improvement and resumption of her premorbid level of functioning. We discuss the relevant literature on the use of ECT in patients with intellectual disability.
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