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Published on: January 19, 2016
Synthesis of (E)- and (Z)-alpha,beta-Difluorourocanic Acid
Jan Hajduch1, Bohumil Dolenský, Shinichi Yoshida
1Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
Abstract:
Horner-Emmons fluoroolefination of an aryl aldehyde followed by introduction of a second fluorine via "FBr" addition provides an original approach to the preparation of 1-alkyl-2-aryl-1,2-difluoroethenes. The utility of this procedure is demonstrated by the preparation of (E and Z)-alpha,beta-difluorourocanic acid.
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