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Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

Paternal age and common mental disorders.

Saroja Krishnaswamy¹, Kavitha Subramaniam, Haymanth Indran

¹Department of Psychiatry, Penang Medical College, Penang, Malaysia. Saroja54@hotmail.com

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry

|February 5, 2009

Summary

Fathers under 20 and over 50 years old had children with higher risks of developing common mental disorders (CMD). This suggests paternal age is a significant factor in offspring mental health outcomes.

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Published on: February 14, 2014

Area of Science:

Psychiatry
Epidemiology
Genetics

Background:

Existing literature suggests a link between advanced paternal age and psychosis, but evidence for common mental disorders (CMD) is less conclusive.
This study investigates the association between paternal age at conception and the risk of CMD in offspring.

Purpose of the Study:

To elucidate the relationship between paternal age at birth and the incidence of common mental disorders in progeny during adulthood.
To identify specific paternal age groups associated with increased risk for CMD.

Main Methods:

A sub-study utilizing data from a larger Malaysian mental disorder epidemiology survey.
Diagnosis of CMD was performed using the Clinical Interview Schedule-Revised (CIS-R) instrument via the Programmed Questionnaire System (PROQSY).
Logistic regression analysis was employed to assess the association between paternal age and CMD, controlling for covariates like age, gender, ethnicity, and family history.

Main Results:

Offspring born to fathers aged 19 or younger, and those born to fathers aged 50 or older, exhibited elevated rates of CMD (10% and 25% respectively).
Paternal age of 19 and below was associated with an odds ratio (OR) of 2.89 (95% CI: 1.1-7.6) for CMD.
Paternal age of 50 and above was associated with a higher OR of 4.28 (95% CI: 1.4-12.7) for CMD.

Conclusions:

Paternal age at conception is a significant risk factor for common mental disorders in offspring.
Potential contributing factors include sperm immaturity in younger fathers, germline mutations in older fathers, and environmental or psychosocial influences.