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Paracrine Signaling

Paracrine Signaling

Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...

Paracrine Signaling

Paracrine Signaling

Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...

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Related Experiment Video

Updated: Jun 25, 2026

A Proximal Culture Method to Study Paracrine Signaling Between Cells

A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

Producing and quantifying enriched para-H2.

Brian A Tom¹, Siddhartha Bhasker, Yuki Miyamoto

¹Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

The Review of Scientific Instruments

|February 5, 2009

Summary

This summary is machine-generated.

We developed a versatile converter to produce highly enriched para-hydrogen (para-H2) for scientific use. This technology enables high-purity para-H2 production and improved measurement techniques.

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Area of Science:

Physics
Chemistry
Materials Science

Background:

Para-hydrogen (para-H2) is crucial for various scientific applications.
Current technologies for para-H2 production and measurement are not widely accessible.

Purpose of the Study:

To design and construct a versatile standalone converter for producing para-H2.
To improve methods for quantifying para-H2 enrichment.

Main Methods:

Developed a novel para-H2 converter.
Utilized thermal conductance, Nuclear Magnetic Resonance (NMR), and solid hydrogen impurity spectroscopy for para-H2 quantification.

Main Results:

Achieved para-H2 enrichments exceeding 99.99%.
Enabled continuous flow rates up to 0.4 standard liters per minute (SLM).
Discussed para-H2 storage and back-conversion rates.

Conclusions:

The developed converter offers a reliable method for high-purity para-H2 production.
Improvements in measurement techniques enhance the accuracy of para-H2 enrichment quantification.