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A review of current anti-HCV treatment regimens and possible future strategies
Karin Neukam1, Juan Macías, José A Mira
1Hospital Universitario de Valme, Unidad Clínica de Enfermedades Infecciosas, 41014 Seville, Spain.
Background:
Hepatitis C virus (HCV) infection remains a serious health problem worldwide. The current standard treatment of HCV infection is pegylated interferon-alpha plus ribavirin, but this is clearly not sufficiently effective and tolerable.
Objective:
To review current HCV treatment strategies and future options.
Methods:
Review of major clinical trials or observational studies when no trial is available.
Results/Conclusion:
Rates of sustained virologic response are widely variable, approximately 40-80%, depending on genotype, and even lower when HIV coinfection occurs. New agents, like small molecules that specifically target the HCV life cycle, may improve response rates; but safety is a concern.
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