Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Language Development01:22

Language Development

Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
Language and Cognition01:27

Language and Cognition

Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unpopular patients and compassion fatigue among nurses: a mixed-methods study on emotional burden, workforce well-being, and patient safety.

BMC nursing·2026
Same author

Training Charge Nurse to Lead Second Victim Support: Fostering a Culture of Safety Through Education.

SAGE open nursing·2026
Same author

NDUFS4, a mitochondrial complex I subunit, is essential for T-cell metabolic fitness and immune function.

Frontiers in immunology·2026
Same author

Clinical Variables Associated with Physician-Driven Inclusion in a Special Management Program for Complex Patients.

Journal of clinical medicine·2026
Same author

Respiratory effects of nusinersen treatment in pediatric patients with spinal muscular atrophy types 2 and 3.

European journal of pediatrics·2025
Same author

Genome sequencing provides high diagnostic yield and new etiological insights for intellectual disability and developmental delay.

NPJ genomic medicine·2025

Related Experiment Video

Updated: Jun 25, 2026

Infant Auditory Processing and Event-related Brain Oscillations
06:34

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

Delayed language development due to infantile thiamine deficiency.

Aviva Fattal-Valevski1, Iris Azouri-Fattal, Yoram J Greenstein

  • 1Pediatric Neurology Unit, Sourasky Medical Center, Israel. afatal@post.tau.ac.il

Developmental Medicine and Child Neurology
|February 5, 2009
PubMed
Summary

Infant thiamine (vitamin B1) deficiency from soy formula negatively impacts childhood language development. Children with deficiency showed poorer expressive communication and auditory comprehension, alongside delayed walking.

More Related Videos

Portable Intermodal Preferential Looking (IPL): Investigating Language Comprehension in Typically Developing Toddlers and Young Children with Autism
10:11

Portable Intermodal Preferential Looking (IPL): Investigating Language Comprehension in Typically Developing Toddlers and Young Children with Autism

Published on: December 14, 2012

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm
06:35

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm

Published on: April 28, 2016

Related Experiment Videos

Last Updated: Jun 25, 2026

Infant Auditory Processing and Event-related Brain Oscillations
06:34

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

Portable Intermodal Preferential Looking (IPL): Investigating Language Comprehension in Typically Developing Toddlers and Young Children with Autism
10:11

Portable Intermodal Preferential Looking (IPL): Investigating Language Comprehension in Typically Developing Toddlers and Young Children with Autism

Published on: December 14, 2012

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm
06:35

Examining Recall Memory in Infancy and Early Childhood Using the Elicited Imitation Paradigm

Published on: April 28, 2016

Area of Science:

  • Pediatric Nutrition
  • Developmental Neuroscience
  • Speech-Language Pathology

Background:

  • Thiamine (vitamin B1) is crucial for neurological development.
  • Infant nutrition, particularly soy-based formulas, requires careful monitoring for essential nutrient levels.
  • Early nutritional deficiencies can have long-lasting developmental consequences.

Purpose of the Study:

  • To investigate the long-term effects of thiamine deficiency in infancy on language development.
  • To compare language and cognitive outcomes in children with and without a history of thiamine deficiency.
  • To explore the relationship between thiamine deficiency, motor development, and language acquisition.

Main Methods:

  • A case-control study involving 20 children with documented thiamine deficiency due to soy formula and 20 matched controls.
  • Assessment of receptive and expressive language using the Preschool Language Scale, 3rd edition.
  • Evaluation of mental development (Bayley Scales of Infant Development, 2nd edition), autistic spectrum disorders, and neurological status.

Main Results:

  • Children with a history of thiamine deficiency exhibited significantly poorer expressive communication (p<0.001) and auditory comprehension (p<0.001).
  • The thiamine-deficient group also showed significantly lower Mental Developmental Index scores (p<0.001) and delayed age at independent walking (p=0.001).
  • A negative correlation was observed between receptive language scores and age at independent walking, indicating poorer language skills were associated with later walking (r=-0.601, p=0.005).

Conclusions:

  • Infancy thiamine deficiency, even from soy-based formula, can adversely affect childhood language development.
  • The findings highlight the critical role of thiamine in early brain development, impacting both cognitive and motor milestones.
  • This study underscores the importance of adequate thiamine levels in infant nutrition to prevent developmental deficits.