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Arterial cardiovascular events, statins, low-dose aspirin and subsequent risk of venous thromboembolism: a

H T Sørensen1, E Horvath-Puho, K K Søgaard

  • 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus C, Denmark. hts@dce.au.dk

Journal of Thrombosis and Haemostasis : JTH
|February 5, 2009
PubMed

Insights

Patients with arterial cardiovascular events face a short-term increased risk of venous thromboembolism. Statins may reduce this risk, while aspirin use shows no association with venous thromboembolism.

Area of Science:

  • Cardiovascular Medicine
  • Thrombosis Research
  • Pharmacological Epidemiology

Background:

  • Conflicting data exist on the association between atherosclerotic disease and venous thromboembolism (VTE).
  • The role of aspirin and statins in VTE risk remains unclear.

Purpose of the Study:

  • To investigate the association between arterial cardiovascular events, statin use, and low-dose aspirin use with the risk of venous thromboembolism.
  • To clarify the short-term and long-term risks of VTE following arterial events.

Main Methods:

  • Population-based case-control study.
  • Involved 5,824 patients with VTE and 58,240 controls.
  • Logistic regression analysis adjusted for confounding factors.

Main Results:

  • Arterial cardiovascular events, particularly within 3 months of myocardial infarction or stroke, significantly increased VTE risk.
  • Long-term history of myocardial infarction showed a modest increase in VTE risk.
  • Current statin use was associated with a reduced risk of VTE (RR=0.74).
  • Aspirin use was not significantly associated with VTE risk.

Conclusions:

  • Cardiovascular events pose a short-term heightened risk for venous thromboembolism.
  • Statins may offer a protective effect against VTE, whereas aspirin does not.
  • Residual confounding cannot be excluded due to the non-randomized study design.
Abstract

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