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Complete remission of primary plasma cell leukemia with bortezomib, doxorubicin, and dexamethasone: a case report
Steven M Chan1, Tracy George, Athena M Cherry
1Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. brunom@stanford.edu.
Background:
Plasma cell leukemia (PCL) is a rare lymphoproliferative disorder considered to be a variant of multiple myeloma. It is an aggressive disease with a poor clinical response to standard chemotherapeutic agents.
Case Presentation:
A novel regimen consisting of bortezomib, doxorubicin, and dexamethasone is currently under active evaluation for the treatment of multiple myeloma. We employed this combination as front-line chemoinduction therapy for a case of primary PCL.
Conclusion:
Complete remission was achieved with rapid normalization of hematologic parameters. The combination of bortezomib, doxorubicin and dexamethasone demonstrates promise in the treatment of PCL.
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