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In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

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Updated: Jun 25, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Individualizing FSH dose for assisted reproduction using a novel algorithm: the CONSORT study.

F Olivennes¹, C M Howles, A Borini

¹francois.olivennes@gmail.com

Reproductive Biomedicine Online

|February 5, 2009

Summary

This summary is machine-generated.

The CONSORT dosing algorithm individualizes recombinant human FSH (r-hFSH) doses for assisted reproduction. This pilot study showed adequate oocyte yield and good pregnancy rates, suggesting algorithm adjustments could lower cancellation rates.

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Last Updated: Jun 25, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

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Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

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Published on: October 24, 2025

Area of Science:

Reproductive Endocrinology
Assisted Reproductive Technologies

Background:

Individualized dosing of recombinant human FSH (r-hFSH) is crucial for optimizing outcomes in assisted reproduction.
The CONSORT algorithm aims to personalize r-hFSH doses based on patient characteristics.

Purpose of the Study:

To evaluate the efficacy and safety of the CONSORT dosing algorithm in normo-ovulatory women undergoing assisted reproduction.
To assess oocyte retrieval numbers and clinical pregnancy rates using algorithm-assigned r-hFSH doses.

Main Methods:

A prospective, uncontrolled, international pilot study involving 18 centers.
The CONSORT algorithm assigned follitropin alpha doses based on basal FSH, BMI, age, and antral follicle count.
Dose adjustments were primarily made to prevent ovarian hyperstimulation syndrome (OHSS).

Main Results:

Median oocyte retrieval was 9.0 across all groups.
Clinical pregnancy rates per cycle started ranged from 31.3% to 50.0% across different dose groups.
Higher than expected cancellation rates due to inadequate response were observed in the 75 IU group.

Conclusions:

The CONSORT algorithm demonstrated potential for achieving adequate oocyte yield and favorable pregnancy rates in assisted reproduction.
Further refinement of the algorithm may be necessary to reduce cancellation rates associated with suboptimal ovarian response.