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BSA-modified polyethersulfone membrane: preparation, characterization and biocompatibility.

Zongbin Liu¹, Xiaopei Deng, Meng Wang

¹College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China.

Journal of Biomaterials Science. Polymer Edition

|February 5, 2009

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Modified polyethersulfone membranes with albumin improved biocompatibility. This reduces unwanted protein adsorption and enhances endothelial cell adhesion, making them promising for biomedical applications.

Area of Science:

Biomaterials Science
Polymer Chemistry
Surface Modification

Background:

Polyethersulfone (PES) membranes are widely used but can suffer from poor biocompatibility.
Surface modification is crucial for enhancing the performance of biomaterials.

Purpose of the Study:

To develop a biocompatible polyethersulfone (PES) membrane through surface modification.
To evaluate the protein adsorption, platelet adhesion, and endothelial cell response on the modified membrane.

Main Methods:

Blending PES with acrylic acid (AA) and N-vinyl pyrrolidone (VP) co-polymer.
Immobilizing bovine serum albumin (BSA) onto the modified membrane surface.
Characterization using SEM, XPS, and CD spectroscopy; evaluation of protein adsorption, platelet adhesion, and cell proliferation (MTT assay).

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Main Results:

Successful blending of PES with P(VP-AA) co-polymer and immobilization of BSA confirmed by XPS.
Significantly reduced protein adsorption from plasma solutions onto the modified membrane.
Enhanced endothelial cell adhesion and proliferation on the BSA-immobilized PES surface.

Conclusions:

The BSA-modified PES membrane exhibits improved hemocompatibility and enhanced endothelial cell response.
This surface modification strategy offers a promising approach for developing advanced biomaterials.