Related Experiment Video
Updated: Jun 25, 2026

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation
Published on: March 15, 2018
[Development of the role of micrornas regulation in osteogenesis]
Zihong Lin1, Senhao Lin, Yingxiong Huang
1Department of Joint Surgery, First Affiliated Hospital of Zhongshan University, Guangzhou Guangdong, 510080, P.R. China.
Objective:
To review the progress, controversy and trend in the regulation and mechanism of the microRNAs (miRNAs) during the osteogenesis.
Methods:
Recent literature concerning regulation and mechanism of the miRNAs during the osteogenesis was extensively reviewed, summarized and analyzed.
Results:
Recently miRNAs was a hot topic for osteogenesis. More and more materials showed its important role in ossification, but its definite mechanism was not clear.
Conclusion:
Osteogenesis can be strengthened by miRNAs technology, which has a bright future and may also provide the molecular mechanism. The study on miRNAs of osteogenesis can provide a model to analyze and compare the osteogenetic effects of novel drugs.
Related Concept Videos
MicroRNAs
MicroRNAs
MicroRNAs
Osteoclasts in Bone Remodeling
Bone Formation by Intramembranous Ossification
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Regulation of Expression Occurs at Multiple Steps
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...