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Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
Published on: October 31, 2019
Polyoxygenated methyl cyclohexanoids from a terrestrial ampelomyces fungus
Huiye Zhang1, Jinghua Xue, Ping Wu
1CAS Key Laboratory for Preservation and Sustainable Utilization of Plant Resources, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
Abstract:
Seven structurally related new polyoxygenated methyl cyclohexanoids, ampelomins A-G (1-7), were isolated from the mycelial solid culture of a soil-derived Ampelomyces fungus. Their structures were determined by spectroscopic and chemical means. Ampelomins A (1), C (3), E (5), and G (7) exhibited weak activity against alpha-glucosidase with IC(50) values of 1.74-5.93 mM, and ampelomin A (1) showed moderate antibacterial activity with MIC(90) values ranging from 202.4 to 1015.9 microM. A plausible polyketide biogenetic pathway is postulated for these compounds.
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