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Novel human parechovirus from Brazil.
Jan Felix Drexler1, Klaus Grywna, Andreas Stöcker
1University Hospital Prof Edgard Santos, Federal University of Bahia, Salvador, Brazil.
Emerging Infectious Diseases
|February 6, 2009
Summary
Human parechoviruses (HPeVs) were found in over 16% of enteritis cases in young children in Brazil. Researchers identified a new strain, human parechovirus 8, through whole genome sequencing.
Area of Science:
- Virology
- Pediatric Infectious Diseases
- Molecular Epidemiology
Background:
- Human parechoviruses (HPeVs) are emerging viral pathogens associated with various human illnesses, particularly in children.
- Enteritis is a common condition in young children, and viral etiologies are significant contributors.
- Surveillance for HPeV in different geographical regions is crucial for understanding its prevalence and genetic diversity.
Purpose of the Study:
- To investigate the prevalence of human parechoviruses (HPeVs) in children with enteritis in Salvador, Brazil.
- To identify and characterize novel HPeV strains circulating in the region.
Main Methods:
- Retrospective analysis of stool samples from children under six years of age presenting with enteritis.
- Detection of HPeVs using reverse transcription-polymerase chain reaction (RT-PCR).
- Whole genome sequencing for characterization of detected viral strains.
Main Results:
- Human parechoviruses (HPeVs) were detected in 16.1% of the 335 stool samples analyzed.
- A novel HPeV strain was identified through whole genome sequencing.
- The novel strain was designated as human parechovirus 8 (HPeV8).
Conclusions:
- HPeVs are a notable cause of enteritis in young children in Salvador, Brazil.
- The identification of HPeV8 highlights the ongoing evolution and emergence of new HPeV genotypes.
- Further research is warranted to understand the clinical significance and epidemiology of HPeV8.
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