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Related Experiment Video

Updated: Jun 25, 2026

Injection of Porcine Adipose Tissue-Derived Stroma Cells via Waterjet Technology

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Published on: November 23, 2021

Direct jetting approaches for handling stem cells.

Napachanok Mongkoldhumrongkul¹, James M Flanagan, Suwan N Jayasinghe

¹BioPhysics Group, Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.

Biomedical Materials (Bristol, England)

|February 6, 2009

Summary

Direct cell jetting methods, including bio-electrosprays and aerodynamically assisted bio-jetting, safely handle stem cells. These techniques show promise for advancing tissue engineering and regenerative medicine applications.

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Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

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Published on: March 17, 2023

Area of Science:

Biotechnology
Regenerative Medicine
Cell Biology

Background:

Direct cell handling via jetting methods has shown promise for tissue engineering.
Previous studies focused on primary cells, necessitating investigation into stem cell applications.
Stem cells are crucial for regenerative medicine, requiring validated handling techniques.

Purpose of the Study:

To investigate the efficacy and safety of bio-jetting techniques for stem cell handling.
To establish proof-of-principle for applying bio-electrosprays and aerodynamically assisted bio-jetting to stem cells.
To evaluate the impact of these jetting methods on stem cell viability and integrity.

Main Methods:

Utilized bio-electrospray and aerodynamically assisted bio-jetting for stem cell manipulation.
Assessed cellular viability over a 72-hour period post-jetting.
Performed flow cytometry and apoptosis assays to detect cellular damage.

Main Results:

Stem cells handled by bio-jetting methods demonstrated high cellular viability compared to controls.
Flow cytometry and apoptosis assays indicated no significant gross cellular damage.
The study provides initial evidence for the safe application of these techniques to stem cells.

Conclusions:

Bio-electrosprays and aerodynamically assisted bio-jetting are viable methods for safe stem cell handling.
These findings support the progression of jetting technologies for advanced tissue engineering and regenerative medicine.
Further research is warranted to fully explore the potential of these techniques in clinical applications.