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A novel versipelostatin analogue, versipelostatin F isolated from Streptomyces versipellis 4083-SVS6
Jun-Ya Ueda1, Shuhei Chijiwa, Motoki Takagi
1Biomedicinal Information Research Center (BIRC), National Institute of Advanced Industrial Science and Technology (AIST), 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan.
The Journal of Antibiotics
|February 6, 2009
Abstract:
A novel versipelostatin (1) analogue, versipelostatin F (2) was isolated from Streptomyces versipellis 4083-SVS6. The structure of 2 was determined by the analyses of the spectroscopic data. Compound 2 inhibited the expression of GRP78 induced by 2-deoxyglucose with an IC(50) value of 0.3 muM, which is 10-times more potent compared with that of 1.
