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Updated: Jun 25, 2026
Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma
Published on: November 11, 2021
Diffuse large B-cell lymphoma with coexpression of CD3 in a pediatric patient: a case report, review of the
Jeremy C Wallentine1, Sherrie L Perkins, Sheryl R Tripp
1Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA. Jeremy.wallentine@hsc.utah.edu
Abstract:
The aberrant expression of T-cell antigens on B-cell-derived non-Hodgkin lymphomas has been described. However, the expression of the lineage-specific T-cell antigen, CD3, in hematologic malignancies is exceedingly rare and to the best of our knowledge has not been reported in pediatric patients. Here we describe the first case of a CD3+ diffuse large B-cell lymphoma in a 9-year-old male patient that is well documented by immunohistochemistry. In addition, results of a tissue microarray study composed of B-cell-derived non-Hodgkin lymphomas (n=77) and reactive lymphoid hyperplasia (n=13) dual stained for PAX5/CD3 are also reported.
