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Related Concept Videos

Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: Jun 25, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Immunosuppression and melanocyte proliferation.

Edoardo Zattra1, Anna Belloni Fortina, Matteo Bordignon

  • 1University of Padua, Padova, Italy.

Melanoma Research
|February 6, 2009
PubMed
Summary

The immune system restrains melanocyte proliferation, but immunosuppression can lead to eruptive nevi. Further research is needed to understand immunosuppression

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

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Last Updated: Jun 25, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Area of Science:

  • Immunology
  • Dermatology
  • Oncology

Background:

  • Melanocytes, pigmented cells from neural crest, are normally controlled by the immune system.
  • Eruptive nevi following immunosuppression suggest a key immune role in limiting melanocyte proliferation.

Purpose of the Study:

  • To review the impact of immunosuppressive regimens on melanocyte proliferation.
  • To analyze the eruptive nevi phenomenon and its link to immune system dysfunction.
  • To explore the role of immunosuppression in melanoma development.

Main Methods:

  • Literature review of studies on immunosuppression, melanocyte proliferation, and skin cancer.
  • Analysis of clinical observations, particularly eruptive nevi in immunosuppressed individuals.
  • Comparison of immune system's role in nonmelanoma skin cancer versus melanoma genesis.

Main Results:

  • The immune system plays a critical role in restraining melanocyte proliferation.
  • Immunosuppression can lead to an inability of the immune system to inhibit melanocyte proliferation, causing eruptive nevi.
  • The role of immunosuppression in melanoma genesis remains unclear, despite established links to nonmelanoma skin cancer.

Conclusions:

  • Clinical evidence strongly supports the immune system's pivotal role in controlling melanocyte proliferation.
  • The dichotomy between eruptive nevi and low melanoma incidence in transplant patients warrants further investigation into melanoma immunogenicity.