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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Related Experiment Video

Updated: Jun 25, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Prostate cancer: the new landscape.

Judd W Moul1, Vladimir Mouraviev, Leon Sun

  • 1Division of Urologic Surgery and Duke Prostate Center (DPC), Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA. judd.moul@duke.edu

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Summary

The prostate cancer landscape is shifting, with more low-risk cases. Active surveillance and focal therapy offer alternatives to traditional treatments for localized prostate cancer.

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Area of Science:

  • Oncology
  • Urology

Background:

  • The prostate cancer landscape in the US is evolving, with significant changes in patient demographics and disease characteristics.
  • Recent data indicate an increasing proportion of patients diagnosed with low-risk prostate cancer.

Purpose of the Study:

  • To review the current state of newly diagnosed prostate cancer in the US.
  • To discuss emerging noninvasive and minimally invasive treatment options for prostate cancer.

Main Methods:

  • Review of recent clinical data and pathological findings.
  • Analysis of treatment trends for localized prostate cancer.

Main Results:

  • A growing population of prostate cancer patients exhibits low-risk features, suggesting a need to reconsider treatment strategies.
  • Active surveillance and focal ablative therapy are emerging as viable alternatives for select low-risk patients, challenging the dominance of radical prostatectomy and whole-gland radiation.

Conclusions:

  • The maturation of the prostate-specific antigen (PSA) era has led to stage migration and an increase in very low-volume, low-grade prostate cancer.
  • While active surveillance suits some patients, managing disease progression remains a challenge.
  • Organ-sparing focal therapy presents a promising option, balancing cancer control with quality of life by bridging the gap between surveillance and whole-gland treatments.