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Updated: Jun 25, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
Non-involuting congenital haemangioma associated with high-output cardiomyopathy
Patrick Cole1, Yoav Kaufman, Denise Metry
1Department of Plastic Surgery, Baylor College of Medicine, Houston, TX, USA. pdcole@bcm.tmc.edu
Abstract:
Non-involuting congenital haemangioma (NICH) is a rare cutaneous vascular tumour about which little is known. Fully formed at birth, NICH enlarges proportionally with age but fails to involute as most infantile haemangiomas do. In addition to this unique clinical character, NICH demonstrates several distinct features. Doppler and magnetic resonance imaging (MRI) studies reveal persistent high-flow arterial feeders and a tumour-like capillary blush; however, NICH fails to demonstrate early venous opacification in contrast to arteriovenous malformation (AVM). NICH lesions also contain microscopic dermal arteriovenous fistulas as well as prominent interlobular veins. Here, we present the first known case of NICH-related high-output cardiomyopathy in a 2-year-old boy.
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