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Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
Diagnosing nonneoplastic lesions in nephrectomy specimens.
Luan D Truong1, Steven S Shen, Moon-Hyang Park
1Department of Pathology, The Methodist Hospital and Research Institute, 6565 Fannin Street, Houston, TX 77030, USA. ltruong@tmhs.org
Archives of Pathology & Laboratory Medicine
|February 7, 2009
Summary
Nonneoplastic kidney lesions are common in nephrectomy specimens, often overlooked despite their prognostic significance. Recognizing these changes is crucial for accurate diagnosis and guiding patient treatment.
Area of Science:
- Nephrology
- Pathology
- Oncology
Background:
- Nonneoplastic changes frequently occur in nephrectomy specimens from renal neoplasms.
- These changes, though prognostically important, are often overlooked.
- Nephrectomy is also performed for nonneoplastic lesions like urinary obstruction and end-stage renal disease.
Purpose of the Study:
- To outline nonneoplastic lesions found in nephrectomy specimens.
- To highlight diagnostic caveats and clinicopathologic correlations for these lesions.
Main Methods:
- Literature review.
- Analysis of personal experience.
- Review of case materials from authors' institutions.
Main Results:
- Nonneoplastic lesions are present in 90% of nephrectomy specimens for renal neoplasms.
- Hypertensive nephrosclerosis and diabetic nephropathy are the most frequent medical kidney diseases observed.
- Conditions necessitating nephrectomy include advanced urinary obstruction and end-stage renal disease, sometimes with acquired cystic changes.
- Superimposing lesions like infections or papillary necrosis can complicate diagnosis in obstructive nephropathy.
- Renal neoplasms can arise in end-stage renal disease without cystic changes.
Conclusions:
- Nonneoplastic changes in nephrectomy specimens are frequent but often unrecognized.
- Awareness of these conditions and their diagnostic features is essential for accurate clinicopathologic correlation.
- Improved recognition can prevent diagnostic problems and guide appropriate patient management.
