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Updated: Jun 25, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Association between ischaemic heart disease and interstitial lung disease: a case-control study
A Ponnuswamy1, R Manikandan, A Sabetpour
1Countess of Chester Hospital, Chester, UK. aravindpdr@yahoo.com
Respiratory Medicine
|February 7, 2009
Summary
This study found no link between statin use and interstitial lung disease. However, a significant association was observed between ischemic heart disease and interstitial lung disease diagnosis.
Area of Science:
- Pulmonology
- Cardiology
- Pharmacology
Background:
- Idiopathic pulmonary fibrosis (IPF) incidence is rising.
- Physician observation suggested a potential link between statin use and IPF.
- A case-control study was designed to explore this association.
Purpose of the Study:
- To investigate the association between statin use and interstitial lung disease (ILD).
- To examine the relationship between comorbid conditions and ILD.
Main Methods:
- A case-control study involving 50 IPF patients and 100 matched controls.
- Data collected included demographics, medical history, and medication use (including statins).
- Controls were recruited from a general gastroenterology clinic.
Main Results:
- No statistically significant association was found between statin use and ILD (OR 1.13, p > 0.05).
- Ischemic heart disease showed a significant association with ILD diagnosis (OR 5.37, p < 0.01).
Conclusions:
- Statin use is not significantly associated with interstitial lung disease.
- Ischemic heart disease is significantly associated with interstitial lung disease.
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