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Related Experiment Video

Updated: Jun 25, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Giant cell arteritis and mortality.

R Wade Crow1, Bradley J Katz, Judith E A Warner

  • 1Department of Ophthalmology and Visual Sciences, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|February 7, 2009
PubMed
Summary
This summary is machine-generated.

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Giant cell arteritis (GCA) significantly increases mortality risk in the first five years post-diagnosis. This study found GCA patients had shorter median survival and lower 5-year survival rates compared to controls.

Area of Science:

  • Rheumatology
  • Internal Medicine
  • Epidemiology

Background:

  • Giant cell arteritis (GCA) is a systemic vasculitis affecting the elderly.
  • GCA is linked to severe complications like blindness and stroke.
  • Previous research on GCA and mortality yielded conflicting results.

Purpose of the Study:

  • To investigate the association between Giant cell arteritis (GCA) and increased mortality.
  • To compare survival rates of GCA patients with age- and gender-matched controls.

Main Methods:

  • A cohort of 44 biopsy-proven Giant cell arteritis (GCA) cases was identified.
  • 100 age- and gender-matched controls were selected for each case from the Utah Population Database.
  • Median survival time and 5-year cumulative survival were analyzed.

Related Experiment Videos

Last Updated: Jun 25, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Main Results:

  • GCA patients had a median survival of 3.71 years versus 8.34 years for controls (p=0.04).
  • Five-year cumulative survival was 35% for GCA cases compared to 67% for controls (p<0.001).
  • Survival curves converged around 11.12 years post-diagnosis.

Conclusions:

  • Giant cell arteritis (GCA) is associated with a significantly higher risk of mortality within five years of diagnosis.
  • Early diagnosis and management of GCA are crucial for improving patient outcomes.