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[Cardiovascular disturbances in acromegaly]

Daniela Fedrizzi1, Mauro Antonio Czepielewski

  • 1Unidade de Neuroendocrinologia, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre. danifedrizzi@hotmail.com

Arquivos Brasileiros De Endocrinologia E Metabologia
|February 7, 2009
PubMed

Insights

Acromegaly, caused by excess growth hormone (GH) and insulin-like growth factor 1 (IGF-1), leads to serious cardiovascular issues like cardiomyopathy and arrhythmias. Effective treatment can improve these conditions and patient survival.

Area of Science:

  • Endocrinology
  • Cardiology
  • Internal Medicine

Background:

  • Acromegaly, a disorder of excess growth hormone (GH) and insulin-like growth factor 1 (IGF-1), significantly impacts cardiovascular health.
  • Cardiovascular complications are the primary cause of increased mortality in acromegaly patients.

Purpose of the Study:

  • To review the clinical and prognostic aspects of cardiovascular disorders in acromegaly.
  • To evaluate the effects of acromegaly treatment on cardiovascular manifestations and patient survival.

Main Methods:

  • Literature review of clinical studies and case reports on acromegaly and cardiovascular disease.
  • Analysis of the pathophysiology, clinical presentation, and treatment outcomes of cardiovascular complications.

Main Results:

  • Acromegalic cardiomyopathy progresses from a hyperdynamic state to hypertrophy, diastolic dysfunction, and potentially systolic dysfunction and heart failure.
  • Other significant cardiovascular issues include arrhythmias, heart valve disease (mitral/aortic), ischemic heart disease, hypertension, and metabolic disorders.

Conclusions:

  • Cardiovascular complications are a major determinant of prognosis in acromegaly.
  • Treatment of acromegaly can positively impact cardiovascular health and improve patient survival, highlighting the importance of timely diagnosis and management.

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