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Updated: Jun 25, 2026

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
Published on: September 5, 2016
Ribosomal frameshifting: an emerging drug target for HIV
Peter C Gareiss1, Benjamin L Miller
1University of Rochester, Department of Dermatology, Rochester, New York, NY 14642, USA.
Abstract:
Combating HIV currently remains one of the key public health challenges. While immense effort has been invested in the development of HIV-targeted therapeutic agents, interfering with protein synthesis is a relatively unexplored area. HIV has an absolute requirement for a -1 ribosomal frameshift event during translation that constitutes a potentially attractive target for interfering with the viral life cycle. Research suggests that while a considerable amount of investigation is still required, targeting frameshifting in HIV with small molecules, peptides and oligonucleotides is feasible.
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