Related Experiment Video
Updated: Jun 25, 2026

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
Published on: July 2, 2021
Etiology of developmental hip dysplasia or dislocation: review article
Insights
Developmental dysplasia or dislocation of the hip (DDH) is primarily caused by mechanical and postural factors during fetal development. Genetic influences play a secondary role in hip instability.
Area of Science:
- Orthopedics
- Developmental Biology
- Genetics
Background:
- The etiology of developmental dysplasia or dislocation of the hip (DDH) lacks consensus in scientific literature.
- The precise mechanism of hip dislocation or subluxation in the perinatal period remains poorly understood.
- Various terms, including congenital dislocation of the hip (CDH), are used interchangeably for the same condition.
Purpose of the Study:
- To review existing theories on hip dysplasia/dislocation.
- To clarify predisposing factors and natural history.
- To establish appropriate nomenclature for hip instability.
Main Methods:
- Literature review of published theories on hip dysplasia/dislocation.
- Analysis of etiological factors, focusing on mechanical and genetic influences.
- Examination of intra-uterine posture and pressure dynamics.
Main Results:
- Mechanical factors, particularly intra-uterine posture (hip flexion, adduction, external femoral rotation), are identified as primary causes of hip instability.
- Abnormal pressure on the greater trochanter contributes to the supero-posterior expulsion of the femoral head.
- Genetic factors are considered secondary but can influence the natural history of DDH.
Conclusions:
- Understanding mechanical and postural predisposing factors is crucial for effective prevention and treatment of DDH.
- A unified nomenclature is needed to accurately describe hip instability conditions.
- Mechanical factors are the predominant drivers of hip dislocation/subluxation, with genetics playing a supporting role.
Abstract:
There is no consensus in the literature regarding the impact of several, so-called, etiological factors in the appearance of developmental dysplasia or dislocation of the hip (DDH). Furthermore, the mechanism explaining the appearance of a dislocated or subluxated hip in the perinatal period is not well defined. The latter explains, as well, the different terms used to describe the same clinical entity. Terms like congenital dislocation of the hip (CDH), developmental dysplasia/dislocation of the hip or teratological dislocation of the hip are usually applied for the description of the same condition. Constitutional and mechanical disorders are accused of encouraging the evolution of an antenatal or neonatal hip towards instability, subluxation or even dislocation. An understanding of the predisposing factors as well as the natural history is essential in order to prevent and/or treat them effectively as well as to decide on the most appropriate nomenclature. A review of the multiple published theories affirms that the determining predisposing factors for hip dislocation or subluxation are mechanical and are associated with intra-uterine posture in full hip flexion, adduction and external femoral rotation together with abnormal pressure on the greater trochanter tending to expel the femoral head in a supero-posterior direction relative to the acetabulum. The role of genetic factors is secondary, but present, and can influence the natural history of a patient if the primary mechanical and postural factors are not inhibited.
Related Concept Videos
Development of the Limb Synovial Joints
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Bones of the Lower Limb: Femur and Patella
Degenerative Disc Disease I: Introduction
Teratogenicity
Degenerative Disc Disease ll: Pathophysiology
