Etiology of developmental hip dysplasia or dislocation: review article

G Koureas1, P Wicart, R Seringe

  • 1Department of Paediatric Surgery, Saint-Vincent-de-Paul Hospital (APHP), Paris, France. gkoureas@yahoo.com

Insights

Developmental dysplasia or dislocation of the hip (DDH) is primarily caused by mechanical and postural factors during fetal development. Genetic influences play a secondary role in hip instability.

Area of Science:

  • Orthopedics
  • Developmental Biology
  • Genetics

Background:

  • The etiology of developmental dysplasia or dislocation of the hip (DDH) lacks consensus in scientific literature.
  • The precise mechanism of hip dislocation or subluxation in the perinatal period remains poorly understood.
  • Various terms, including congenital dislocation of the hip (CDH), are used interchangeably for the same condition.

Purpose of the Study:

  • To review existing theories on hip dysplasia/dislocation.
  • To clarify predisposing factors and natural history.
  • To establish appropriate nomenclature for hip instability.

Main Methods:

  • Literature review of published theories on hip dysplasia/dislocation.
  • Analysis of etiological factors, focusing on mechanical and genetic influences.
  • Examination of intra-uterine posture and pressure dynamics.

Main Results:

  • Mechanical factors, particularly intra-uterine posture (hip flexion, adduction, external femoral rotation), are identified as primary causes of hip instability.
  • Abnormal pressure on the greater trochanter contributes to the supero-posterior expulsion of the femoral head.
  • Genetic factors are considered secondary but can influence the natural history of DDH.

Conclusions:

  • Understanding mechanical and postural predisposing factors is crucial for effective prevention and treatment of DDH.
  • A unified nomenclature is needed to accurately describe hip instability conditions.
  • Mechanical factors are the predominant drivers of hip dislocation/subluxation, with genetics playing a supporting role.

Related Concept Videos

Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Bones of the Lower Limb: Femur and Patella01:16

Bones of the Lower Limb: Femur and Patella

The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the neck...
Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...