Photogenerated quinone methides as protein affinity labeling reagents
Jiangsong Jiang1, Dexing Zeng, Shuwei Li
1Department of Cell Biology and Molecular Genetics, University of Maryland College Park, College Park, MD 20742, USA.
Chembiochem : a European Journal of Chemical Biology
|February 7, 2009
Abstract:
Photogenerated quinine methides (QMs) can act as highly specific light-controllable protein affinity labeling reagents, broadening their applications to the study of protein-ligand and protein-protein interactions. The reactions between QMs and nucleophiles are less heterogeneous than those of other photogenerated active intermediates such as carbenes and nitrenes, making it easier to identify labeled species.
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