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Less is more: how protein degradation regulates muscle development

T Hoppe1

  • 1Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases at the Institute for Genetics, University of Cologne, Zülpicher Str. 47, 50674 Cologne, Germany. thorsten.hoppe@zmnh.uni-hamburg.de

Ernst Schering Foundation Symposium Proceedings
|February 10, 2009
PubMed
Summary

Muscle development relies on myosin assembly factor UNC-45. Its turnover, regulated by E3 enzymes and CDC-48/p97, is crucial for myofibril organization and muscle maintenance.

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