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Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
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mTOR Signaling and Cancer Progression

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Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Related Experiment Video

Updated: Jun 25, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

[Prostate-specific antigen and telomerase in prostatic cancers].

K A Poliakovskiĭ, A I Glukhov, E G zezerov

    Klinicheskaia Laboratornaia Diagnostika
    |February 10, 2009
    PubMed
    Summary

    Elevated blood prostate-specific antigen (PSA) levels correlate with active telomerase in prostate tissues. This finding is significant for diagnosing prostate cancer (PC) and related conditions.

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    Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

    Published on: March 14, 2014

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    Last Updated: Jun 25, 2026

    Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
    13:19

    Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

    Published on: November 2, 2013

    Murine Prostate Micro-dissection and Surgical Castration
    08:49

    Murine Prostate Micro-dissection and Surgical Castration

    Published on: May 11, 2016

    Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
    07:16

    Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

    Published on: March 14, 2014

    Area of Science:

    • Urology
    • Oncology
    • Biochemistry

    Context:

    • Prostate-specific antigen (PSA) is a biomarker for prostate health.
    • Telomerase activity is implicated in cellular proliferation and cancer.
    • Understanding the relationship between PSA and telomerase is crucial for prostate disease diagnosis.

    Purpose:

    • To investigate the correlation between blood PSA levels and prostatic tissue telomerase activity.
    • To analyze this correlation across different prostate conditions: prostate cancer (PC), high-grade prostatic intraepithelial neoplasia (HG PIN), low-grade prostatic intraepithelial neoplasia (LG PIN), and benign prostatic hyperplasia (BPH).

    Summary:

    • A study of 92 patients examined the link between serum PSA and prostate telomerase activity.
    • Active telomerase was detected in 98% of PC patients, 33% of HG PIN, and 20% of LG PIN cases.
    • Patients with active telomerase in prostate biopsies showed statistically significantly higher blood PSA levels.

    Impact:

    • This research highlights telomerase activity as a potential indicator in prostate biopsies.
    • Findings may contribute to improved diagnostic strategies for prostate cancer and precursor lesions.
    • The correlation suggests a potential pathway for understanding prostate cancer progression.