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Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
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Updated: Jun 25, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Measles virus receptors.

Y Yanagi1, M Takeda, S Ohno

  • 1Department of Virology, Faculty of Medicine, Kyushu University, 812-8582, Fukuoka, Japan. yyanagi@virology.med.kyushu-u.ac.jp

Current Topics in Microbiology and Immunology
|February 10, 2009
PubMed
Summary
This summary is machine-generated.

Measles virus (MV) uses immune cell receptors like Signaling Lymphocyte Activation Molecule (SLAM) and epithelial cell receptors for infection. Understanding these measles virus receptors is key to its tropism and pathogenesis.

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08:32

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Published on: March 2, 2014

Area of Science:

  • Virology
  • Immunology
  • Structural Biology

Background:

  • Measles virus (MV) possesses two envelope glycoproteins: hemagglutinin (H) and fusion protein, mediating attachment and membrane fusion.
  • Signaling lymphocyte activation molecule (SLAM, CD150) is the primary receptor for MV on immune cells, driving lymphotropism and immunosuppression.
  • MV infects epithelial cells via an unidentified receptor, potentially facilitating aerosol transmission, and utilizes CD46 as an alternative receptor in adapted strains.

Purpose of the Study:

  • To elucidate the cellular receptors utilized by Measles virus (MV) for host cell entry.
  • To understand the structural basis of MV receptor-ligand interactions.
  • To advance the comprehension of MV tropism and pathogenesis through receptor identification.

Main Methods:

  • Analysis of the crystal structure of the MV H protein.
  • Implication of various molecules in MV infection.
  • Comparative analysis of receptor binding sites on the H protein.

Main Results:

  • The H protein's crystal structure reveals distinct binding sites for SLAM, CD46, and the epithelial cell receptor.
  • SLAM is identified as the principal receptor for MV on immune cells.
  • CD46 serves as an alternate receptor for vaccine and lab-adapted MV strains.

Conclusions:

  • The identification of specific MV receptors (SLAM, CD46, and an unknown epithelial receptor) clarifies MV tropism.
  • Structural insights into H protein interactions with receptors advance understanding of MV pathogenesis.
  • Further research is needed to confirm the roles of other implicated molecules in MV infection.