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Related Experiment Video

Updated: Jun 25, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Measles virus and CD46.

C Kemper¹, J P Atkinson

¹Division of Rheumatology, St. Louis, MO 63110, USA.

Current Topics in Microbiology and Immunology

|February 10, 2009

Summary

This summary is machine-generated.

Measles virus cell entry was identified in 1993, revealing CD46 as the primary receptor. This discovery significantly advanced understanding of measles pathogenesis and vaccine development.

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Last Updated: Jun 25, 2026

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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

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Published on: September 14, 2010

Area of Science:

Virology
Immunology
Cell Biology

Background:

Measles virus (MV) is highly contagious and a major cause of childhood mortality.
Despite decades of research and vaccine development, MV cell entry mechanisms remained unclear until the 1990s.

Purpose of the Study:

To identify the cell entry receptor(s) for measles virus.
To elucidate the role of identified receptors in MV infection and pathogenesis.

Main Methods:

Transfection of nonsusceptible rodent cells with human CD46.
Infection assays using Edmonston and Halle MV vaccine strains.
Inhibition assays using monoclonal and polyclonal antibodies against CD46.

Main Results:

Transfection with human CD46 rendered rodent cells susceptible to MV infection.
Antibodies targeting CD46 effectively inhibited MV binding and infection.
These findings established CD46 as a functional MV cell entry receptor.

Conclusions:

CD46 acts as a critical cell entry receptor for measles virus.
Understanding the CD46-MV interaction is key for measles pathogenesis and therapeutic strategies.