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Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection
Published on: February 28, 2021
Measles virus interaction with host cells and impact on innate immunity
1CNRS, Université de Lyon 1, FRE3011, IFR 62 Laennec, 69372 Lyon Cedex 08, France. denis.gerlier@univ-lyon1.fr
Current Topics in Microbiology and Immunology
|February 10, 2009
Summary
Measles virus utilizes cellular receptors for entry and interacts with host proteins to replicate and evade immunity. Understanding these partnerships is key to controlling measles virus infection.
Area of Science:
- Virology
- Cell Biology
- Immunology
Background:
- Measles virus, an obligate parasite, engages in numerous interactions with host cellular molecules.
- These partnerships are crucial for viral entry, replication, assembly, budding, and immune evasion.
Purpose of the Study:
- To elucidate the complex interplay between measles virus and cellular proteins.
- To identify key host factors involved in viral lifecycle and pathogenesis.
Main Methods:
- Review of existing literature on measles virus-host interactions.
- Analysis of viral protein functions and their cellular binding partners.
- Examination of host innate immune responses to measles virus infection.
Main Results:
- Measles virus employs dual receptors (CD150, epithelial receptor) for entry; vaccine strains use CD46.
- Hsp72 interacts with viral N protein, regulating transcription/replication.
- Viral P and V proteins interfere with interferon signaling pathways (RIG-I, MDA5, STAT1, Jak1).
- Viral H and P proteins modulate TLR signaling pathways (TLR2, TLR4).
Conclusions:
- Significant gaps exist in understanding intracellular viral-cellular protein partnerships.
- Further research is needed to fully comprehend the physiopathological outcomes of these interactions.
- Targeting these host-virus interactions may offer novel therapeutic strategies.
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