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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Related Experiment Video

Updated: Jun 25, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Testosterone treatment in elderly men.

U Srinivas-Shankar1, D Sharma

  • 1Department of Diabetes and Endocrinology, The Royal Liverpool and Broadgreen University, Hospitals NHS Trust, Liverpool, L78XP, UK. usrinivas@manchester.ac.uk

Advances in Therapy
|February 10, 2009
PubMed
Summary
This summary is machine-generated.

Testosterone replacement therapy may benefit aging men with hypogonadism, improving body composition, strength, and cognition. Careful patient selection and monitoring are crucial due to potential prostate side effects.

Related Experiment Videos

Last Updated: Jun 25, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Area of Science:

  • Endocrinology
  • Geriatrics
  • Men's Health

Background:

  • Testosterone therapy has a long history in treating testicular and hypothalamo-pituitary diseases.
  • There is increasing interest in testosterone's role for aging men, prompting research into male hormone replacement benefits.

Purpose of the Study:

  • To review the indications, contraindications, and benefits of testosterone treatment in aging men.
  • To discuss the adverse effects, advantages, and disadvantages of various testosterone preparations.

Main Methods:

  • Review of existing literature on testosterone therapy.
  • Analysis of different testosterone administration modes (injectable, implants, transdermal, gels, parenteral).
  • Focus on elderly men and associated risks.

Main Results:

  • Testosterone treatment may improve body composition, muscle strength, sexual function, and cognition in hypogonadal men.
  • Transdermal patches, gels, and long-acting parenteral preparations are replacing older methods.
  • Treatment is generally safe with appropriate patient selection and monitoring, but prostate effects are a key concern.

Conclusions:

  • Testosterone therapy offers potential benefits for aging men with hypogonadism.
  • Various administration methods exist, with transdermal and gels suitable for the elderly.
  • Careful monitoring is essential to manage potential adverse effects, particularly on the prostate.