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Updated: Jun 25, 2026

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
Published on: September 12, 2019
[Malignant neoplasms of the female pelvis]
1Klinik für Diagnostische und Interventionelle Radiologie, St. Vincentius-Kliniken Karlsruhe, Südendstrasse 32, 76137 Karlsruhe. prof.lehmann@vincentius-ka.de
Abstract:
Cervical, endometrial and ovarian carcinomas are the main malignant neoplasms of the female pelvis. For CT, a thin-slice venous phase with good bowel contrast is used. For MRI, an anti-peristaltic agent is necessary. Thin-slice T2- weighted TSE images with a high in-plane spatial resolution are particularly suitable for imaging the uterine wall; a parenteral contrast medium is absolutely necessary to demonstrate endometrial and ovarian carcinoma. In the guidelines, MRI is recommended only for cervical cancer FIGO 1b and higher stages; nevertheless, CT and MRI play an important role in preoperative diagnosis of these tumors. Lymph node staging is performed during surgery where possible. In patients with endometrial carcinoma, preoperative staging focuses on the infiltration depth in the myometrium. Preoperative diagnosis of ovarian cancer centers on any tumor spread in the abdomen, and diagnostic imaging methods are designed to provide the surgeon with information about compartments of a possible peritoneal carcinosis that are difficult to see. In patients with incidental findings of ovarian masses, CT and MRI can detect evidence of malignancy, although an exact differential diagnosis is not usually possible in this very heterogeneous group of ovarian tumors.
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