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Alkylating ability of artemisinin after Cu(I)-induced activation
Fatima Bousejra-El Garah1, Marguerite Pitié, Laure Vendier
1Laboratoire de Chimie de Coordination du CNRS, Toulouse cedex 4, France.
Abstract:
The reductive activation of artemisinin by copper(I)-dipyrrin or copper(I)-(2-Clip-Phen) complexes generates an artemisinin derived alkylating species leading to covalent artemisinin-copper complex adducts. The reactivity of the peroxide function of artemisinin toward Cu(I) complexes is similar to that of Fe(II) analogues, even though the reaction is more sluggish and product distribution slightly different.
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