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Updated: Jun 25, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Eremophilane-type sesquiterpene derivatives from Ligularia hodgsonii
Wen-Xian Li1, Ming Lei, Dong-Qing Fei
1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
Abstract:
Eight new highly oxygenated eremophilane-type sesquiterpene derivatives (1- 8), including two norsesquiterpenes, were isolated from an extract of the roots and the aerial parts of Ligularia hodgsonii Hook. Their structures and relative configurations were elucidated by spectroscopic methods, including IR, UV, HR-ESI-MS, and 1D and 2D NMR techniques, as 3 beta-acetoxy-10 beta-hydroxy-6 beta,8 beta-dimethoxyeremophil-7(11)-en-8 alpha,12-olide (1), 3 beta-acetoxy-10 beta-hydroxy-6 beta-methoxyeremophil-7(11),8(9)-dien-8,12-olide (2), 3 beta-acetoxy-10 beta-hydroxy-6 beta,8 alpha-dimethoxyeremophil-7(11)-en-8 beta,12-olide (3), 6 beta-(2'-methylbutanoyloxy)-3 beta-acetoxy-10 beta-hydroxy-8 alpha-methoxyeremophil-7(11)-en-8 beta,12-olide (4), 6 beta-(2'-methylbutanoyloxy)-3 beta-acetoxy-10 beta-hydroxyeremophil-7(11)-en-8 beta,12-olide (5), 3 beta-acetoxy-8-oxoeremophil-6(7),9(10)-dien-12-oic methyl ester (6), 3 beta-acetoxy-6 alpha,7 alpha-epoxy-9(10)-en-8-oxoeremophil-12-nor-11-one (7), and 2-acetyl-5 beta-acetoxy-3a,4,5,6,7,7a-hexahydro-7a beta-hydroxy-3a beta,4 beta-dimethyl-1H-indene (9).
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