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Updated: Jun 25, 2026

Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis
Published on: October 30, 2014
[Fine mapping of a pure paroxysmal kinesigenic dyskinesia family]
Ding Liu1, Guo-liang Li, Chan-juan Chen
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 PR China.
Objective:
To fine map the gene responsible for pure paroxysmal kinesigenic dyskinesia in a Chinese family.
Methods:
Six additional markers flanking the tightly linked markers were chosen in the candidate region resulting from a whole genome-wide scanning and tested by parameter and nonparameter analysis using Linkage and Genehunter softwares to fine map the candidate region.
Results:
Evidence for linkage of the pure paroxysmal kinesigenic dyskinesia to chromosome 3 was further confirmed. A maximum two-lod score of 2.82 at theta=0 was obtained with D3S3669. Critical recombinants place the PKD gene between D3S1314 and D3S1265.
Conclusion:
A new locus of pure paroxysmal kinesigenic dyskinesia (PKD) is localized within a 10.2 cM interval on 3q28-29, between markers D3S1314 and D3S1265.
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